Tocofersolan (TPGS)

1.Tocofersolan(TPGS) iwebata

Rebecca BioTocofersolan (TPGS) FDA kwadoro ka ọ bụrụ ihe nchekwa nchekwa yana ejiri ya mee ihe na usoro nnyefe ọgwụ. Ngwongwo ndu na physicochemical nke TPGS na-enye otutu uru maka ngwa ya na nnyefe ọgwụ dị ka nnukwu biocompatibility, nkwalite ọgwụ solubility, mmụba nke ọgwụ ọjọọ na ọrụ antitumor nhọrọ.

N'ụzọ doro anya, TPGS nwere ike igbochi ọrụ nke P-glycoprotein dabere na ATP ma mee ihe dị ka ihe enyemaka dị ike maka imeri nguzogide ọgwụ ọjọọ (MDR) na tumor. Na nyocha a, anyị bu n'obi ikwurịta ọganihu TPGS na nso nso a na nnyefe ọgwụ gụnyere TPGS dabeere prodrugs, nitric oxide donor and polymers, na unmodified TPGS based formulations. Ngwa ndị a nwere ike na-elekwasị anya n'ịkwalite arụmọrụ nnyefe yana mmetụta ọgwụgwọ nke ndị ọrụ, karịsịa na imeri MDR nke etuto ahụ. Ọ na-egosipụtakwa na nsụgharị ụlọ ọgwụ nke TPGS dabeere nanomedicine ka na-eche ọtụtụ ihe ịma aka ihu, nke na-achọkwu nkọwa zuru ezu banyere ihe onwunwe TPGS na usoro nnyefe dabere n'ọdịnihu.

Njirimara ọgwụ ọgwụ dị iche iche nke vitamin E.

1.1 Vitamin E TPGS, polymer amphiphilic

E TPGS bụ ụdị vitamin E na-enweghị mmiri, nke FDA kwadoro ma na-ejikarị ya na usoro nnyefe ọgwụ dị ka ihe nchekwa nchekwa. Ngwongwo ihe ndu na physicochemical nke TPGS na-enye ọtụtụ uru maka ngwa nnyefe ọgwụ ya dị ka nnukwu biocompatibility, nkwalite ọgwụ ike, mmụba ọgwụ na-emeziwanye, yana ọrụ antitumor nhọrọ.

1.2 Ọdịdị na akụrụngwa

Vitamin E Tocofersolan(d-alpha-tocopheryl polyethylene glycol 1000 succinate ma ọ bụ TPGS) bụ ihe soluble mmiri nke vitamin E eke eke, kpụrụ ya na polyethylene glycol 1000 site esterification nke d-alpha-tocopheryl polyethylene glycol succinate. Ọzọkwa, TPGS bụ macromolecule nke nwere ọdụ lipophilic alkyl na isi polar hydrophilic nke nwere ihe amphiphilic (lee foto 2).

Nyocha 2.

Ọdịdị chemical nke Vitamin E Tocofersolan. The lipophile ka hydrophile nha nhata nke TPGS bụ ihe pụrụ iche amphiphilic nhazi. N'ihi ya, ọ bụ ihe siri ike nke nwere ebe ikuku na-agbaze ihe dị ka 41ºC, sitere na odo ruo na agba aja aja. N'okike, ọ dị oke ibu ma nwee ebe dị elu karịa, ya mere a na-ewere ya dị ka emulsifier dị mma na ike solubilizer. The chemical Ọdịdị nke TPGS eji na ọtụtụ formulations / ngwa gosiri na Figure 2, dị ka: 1. Ịkwalite ọgwụ bioavailability, 2. Njirimara nke surfactants nke na-eme ka solubilization nke ọgwụ ọjọọ eme ihe na mmiri soluble, 3. Stabilizer nke amorphous ọgwụ ụdị 4. Inhibiting. mmịpụta nke P-glycoprotein nke na-eme ka ikike ọgwụ dịkwuo mma, 5. Emulsion ụgbọ ala, 6. Na-arụsi ọrụ ike. Ingredient in self-emulsifying formulations, 7. Belata mmebi ọgwụ na-emebi anụ ahụ dermal, 8. Onye na-ebu maka nlekọta ọnya na ọgwụgwọ, 9. Vitamin E mmiri na-edozi mmiri, 10. Fabrication nanosusspensions, 11. Self-microemulsifying na siri ike mbadamba / mgbasa 12. Ngwa ịgba ọgwụ mgbochi ọrịa, 13. nkwalite oriri na-edozi ahụ, 14. Nhazi nke Nano-particles, 15. Micelles, 16. Liposomes, 17. Dabere na prodrug.

TPGS-VE bụ solubilizer na-arụ ọrụ nke ogige dị iche iche nke na-eme ka mmiri na-agbaze na mmiri na-adịghị ike, dị ka steroid, ọgwụ nje, cyclosporins, taxes, wdg. TPGS vitamin E nwere ike ịrụ ọrụ dị ka P-gp inhibitor na ikike dị elu karịa ndị ọzọ na-abụghị ionic surfactants. , dị ka Tween 80, Pluronics na Cremophor EL, iji gbochie ọrụ P-gp.

2. Ihe nkwalite absorption / bioavailability enhancer

Ọtụtụ ọmụmụ gosiri na ụbara bioavailability bụ n'ihi nhazi nke mielle na-eme ka solubility dịkwuo mma, ebe ndị ọzọ gosipụtara na mgbochi P-glycoprotein (P-gp) na-enye aka n'ịbawanye nkwado nkwado.

Nyocha 3.

Ngwa nke vitamin E TPGS na nnyefe ọgwụ .Polyethyeleneglycol (PEG).

2.1 TPGS Njirimara na usoro nnyefe ọgwụ

Ụdị vitamin E nke mmiri-miscible, TPGS, mejupụtara agbụ hydrophilic nke PEG jikọtara na akụkụ hydrophobic nke vitamin E. Dị ka otu usoro amphiphilic si dị, ọ na-egosi ikike nnyefe ọgwụ dị ebube.

3. TPGS dị ka surfactant

Mmiri na-adịghị mma na/ma ọ bụ adịghị ike na-adịghị mma na-anọgide na-abụ nnukwu snag maka ọrụ kachasị nke ọgwụ ọgwụgwọ. Na nnyefe ọgwụ, TPGS nwere ike iji dị ka solubilizer, permeation enhancer, mgbasa, na emulsifier nakwa dị ka a elu stabilizer. A na-ejikarị ya eme ihe maka ọtụtụ ọgwụ na-adịghị mma nke mmiri na-agbaze ma ọ bụ na-emerụ emerụ na mmepụta nke nanodrugs ma ọ bụ usoro ndị ọzọ, tumadi maka klas II na IV Biopharmaceutical Classification System (BCS).

4. Ọrụ TPGS iji chịkwaa mkpụrụ ndụ kansa

4.1 α-Mkpali ụdị oxygen na-arụ ọrụ

4.2 DNA mebiri

4.3 TPGS sitere na prodrugs

5. Mmetụta nke TPGS na ịba

Tocofersolan (TPGS) bụ onye kwesịrị ekwesị maka ọgwụ ọhụrụ na-egbochi ịba, Nchọpụta a egosila na ọgwụgwọ TPGS nke ịba, ọnụ ọgụgụ nlanarị na ụmụ oke ndị nwere nje abụọ ejirila elu dị elu. N'otu aka ahụ, ịdị njọ nke ntanye na-acha anụnụ anụnụ nke Evans na ụbụrụ nke ewepụtara na ụmụ oke ejiri TPGS gwọọ dị ala karịa ọgwụgwọ ụmụ oke na-enwetaghị.

6. TPGS dabeere na polymers na nnyefe ọgwụ

A na-eji polymer TPGS eme ihe n'ọtụtụ ebe na usoro nnyefe ọgwụ, nke nwere ike ịkwalite arụmọrụ nke ọgwụ ahụ, ntinye sel intracellular na ọgwụgwọ ọgwụgwọ na vitro na in vivo.

Usoro dabere na TPGS iji melite ọnụọgụ ọnụ ọgwụ

7. Osteoarthritis

Osteoarthritis (OA) nke ikpere bụ isi ihe kpatara na-adịghị ala ala, erughị eru na ndị agadi, pathogenesis nke ọrịa a ruo ugbu a aghọtabeghị nke ọma. Ntuziaka na-adịbeghị anya na-egosi na nrụgide oxidative, ihe omume ebe ọkwa oxidant gafere nke ndị ọrụ antioxidative, bụ otu n'ime ihe ebumnobi nke OA. ROS gụnyere oxidants nke a na-emepụta n'okpuru ọnọdụ physiological na ahụ mmadụ ma na-achịkwa antioxidants cell, na-eduga na mmebi ọrụ na nhazi nke mkpụrụ ndụ cartilage.

mbukota

Maka ngwaahịa ntụ ntụ, anyị na-ezigakarị ngwaahịa ya na katọn ma ọ bụ eriri fiber. Ụzọ nkwakọ ngwaahịa anyị bụ 1 kg / aluminium bag, 25 kg / box, na 25 kg / barrel. Maka ngwaahịa ụfọdụ nke chọrọ nkwakọ ngwaahịa pụrụ iche n'oge njem, anyị ga-ebu ngwugwu zuru ezu karị.

Transportation

Anyị na-akwado mbupu site na ikuku, oké osimiri, FedEx, DHL, TNT, EMS, UPS, SF, na ndị ọzọ na-ebu.

Anyị laabu na Factory

Dị ka ọkachamara Tocofersolan (TPGS) soplaya, anyị àgwà nnyocha ngalaba na-onwem na kasị elu ule na njirimara ngwá, dị ka UPLC, HPLC, UV na TT (arụ ọrụ Efrata) GC na GC-MS (solvent residue), ICP-MS (Ọla dị arọ), GC/LC-MS-MS (ihe mkpofu pesticide), HPTLC na IR (nchọpụta), ELIASA (Uru ORAC), PPSL (ihe fọdụrụ ikuku), nchọpụta microbial, wdg.

Kpọtụrụ anyị

Ka ilele broshuọ anyị ma ọ bụ kparịta nnukwu iwu Tocofersolan(TPGS), kpọtụrụ anyị at ozi@sxrebecca.com.