Urolithin A bụ eriri afọ metabolite nke ellagic acid nwere antioxidant na mmetụta antiproliferative; ọ na-egbochi uto nke mkpụrụ ndụ T24 na Caco-2 nwere ụkpụrụ IC50 nke 43.9 na 49 μM, n'otu n'otu.

Njirimara anụ ahụ na kemịkalụ nke urolitin A

Urolithin A bụ metabolite nke abụọ nke ogige polyphenol eke ellagitannin. Ọmụmụ ihe ọhụrụ egosila na urolithin A nwere ihe omume dị mkpa dị ndụ, dị ka mgbochi oxidation, mgbochi mkpali, mgbochi ịka nká, na-achịkwa estrogen / androgen na ime ka mitochondrial autophagy. Ya mere, urolithin A na-ekere òkè dị mkpa na mgbochi na ọgwụgwọ nke ọtụtụ ọrịa, dị ka ọrịa kansa, ọrịa obi, ọrịa Alzheimer, ọrịa Parkinson, ọrịa shuga, oke ibu, osteoarthritis, wdg.

Isi mmalite na njirimara nhazi nke urolithin

Urolithin A (UroA) na urolithin B (UroB) bụ nke mbụ kewapụrụ na nkume akụrụ atụrụ dịka metabolites nke ellagic acid. Urolithin eke abụghị ihe a na-ahụkarị na okike, mana dịka metabolite nke tannin ellagic ma ọ bụ ellagic acid, a na-ekesa ya na mmamịrị, nsị na bile nke mammals dị ka mmadụ, oke, oke, ehi na ezi. Espín et al. chọpụtara na urolithin nwere ike ime ka ọ dịkwuo elu na eriri afo na gallbladder nke pigs Iberian, ma ọ dịghị ihe bara uru doro anya na anụ ahụ ndị ọzọ dị ka akwara, abụba, akụrụ, imeju na obi. Nnyocha nnwale na ụmụ oke na ụmụ mmadụ achọpụtala na urolithin na ihe ndị sitere na ya na-eme ka anụ ahụ prostate dịkwuo mma ma na-ekesakwa na anụ ahụ eriri afọ mmadụ.

A na-emepụta Urolitin site na ellagic acid na-efunahụ mgbanaka lactone wee jiri nwayọọ nwayọọ wepụ ya. Mgbe ellagic acid tụfuru mgbanaka lactone ya, a na-ebu ụzọ nweta urolithin M-5 (UroM-5). UroM-5 bụ dehydroxylated n'ọnọdụ dị iche iche iji mepụta ọtụtụ tetrahydroxy urolithin isomers dị ka urolithin D (UroD) na urolithin M-6 (UroM-6). Tetrahydroxy urolithin tụfuru otu hydroxyl iji mepụta trihydroxy urolithins dị ka urolithin C (UroC) na urolithin M-7 (UroM-7). Trihydroxy urolithin tụfuru otu hydroxyl ọzọ iji mepụta dihydroxy urolithins dị ka UroA na urolithin A isomer (isoUroA), na n'ikpeazụ monohydroxy urolithin B (UroB) nwetara. Ọzọkwa, isoUroA dị mfe dehydroxylate iji mepụta UroB karịa UroA. García-Villalba et al. Ọ na-eji in vitro intestinal microbial metabolism nnwale iji chọpụta metabolites nke ellagic acid, UroM-5, UroM-6, UroM-7, UroC, na urolithin E (UroE), na-egosi na nke mbụ urolithin na-emepụta n'okpuru omume. osisi intestinal.

Urolithin A bụ ngwaahịa nke ahịhịa eriri afọ. Mgbe ahụ mmadụ rie akwụkwọ nri na mkpụrụ osisi dịka mkpụrụ pọmigranet, tomato na mkpụrụ osisi, nje bacteria na-egbu egbu na phenolic antioxidants bara ụba na mkpụrụ osisi na akwụkwọ nri ndị dị n'elu na-emeghachi omume iji mepụta urolithin A. N'afọ ndị na-adịbeghị anya, ụfọdụ nchọpụta ziri ezi egosila na urolithin A na-enyere aka. mitochondrial proliferation na-ewusi ọrụ ya ike, si otú ahụ na-akwalite ahụ ike cell, na mmetụta dị mkpa karịsịa na mọzụlụ, ụbụrụ, nkwonkwo na akụkụ ndị ọzọ.

Urolithin A na-erite uru: oke ibu na abụba visceral

Na mgbakwunye, urolitin A na-enyere aka ịkwụsị ibu. Nnwale anụmanụ na 2020 gosiri na ndị otu nyocha ahụ na-enye ụmụ oke oke ibu n'ụzọ anọ: nri nkịtị, nri nwere oke abụba, nri nwere oke abụba agbakwunyere na urolithin A mgbe izu iri gachara, yana nri nwere oke abụba agbakwunyere urolithin B mgbe izu iri gachara. Nsonaazụ ikpeazụ bụ na ìgwè abụọ ahụ nke oke oke ibu agbakwunyere na urolithin nwere mbelata dị ukwuu na ibu na abụba visceral.