Gịnị bụ solubility nke curcumin ntụ ntụ?

Curcumin, ogige odo na-acha odo odo dị na turmeric, enwetala nlebara anya dị ukwuu maka uru ahụike ya. Otú ọ dị, otu n'ime ihe ịma aka ndị bụ isi n'iji ya eme ihe n'ụzọ zuru ezu bụ na solubility ya. Ịghọta solubility nke curcumin nnukwu ntụ ntụ dị oke mkpa maka ịbawanye nnabata ya na ịdị irè ya. N'ime ntuziaka a sara mbara, anyị ga-enyocha n'ime mgbagwoju anya nke curcumin solubility wee chọpụta ụzọ isi kwalite ịdị ndụ ya.

Kedu ka Solubility si emetụta curcumin nnukwu ntụ ntụ absorption?

Ihe solubility nke curcumin ntụ ntụ na-arụ ọrụ dị mkpa n'ịchọpụta nnabata ya na ịdị irè n'ime ahụ mmadụ. Ihe ngwọta adịghị mma nke Curcumin na ngwọta aqueous na-egbochi ike bioavailability ya, nke bụ oke na ọnụego nke ihe na-etinye n'ime ọbara.

Ihe ịma aka Bioavailability

Mbelata nke curcumin na mmiri na-enye nnukwu ihe mgbochi maka nnabata ya na eriri afọ. Mgbe a na-eri ya n'ụdị raw ya, ọ bụ naanị obere akụkụ nke curcumin na-achịkwa ịbanye n'ọbara, na-egbochi mmetụta ọgwụgwọ ya. Nke a na-adịghị mma bioavailability bụ isi sitere na ọdịdị hydrophobic ya, metabolism ngwa ngwa, na mkpochapụ usoro ngwa ngwa.

Mmetụta maka ojiji ọgwụgwọ

Obere solubility nke curcumin ntụ ntụ nwere mmetụta miri emi maka ojiji ya na ngwa ọgwụgwọ. Iji nweta mmetụta physiological bara uru, enwere ike ịchọ ọgwụ curcumin dị elu nke ukwuu, nke nwere ike bụrụ ihe na-adịghị mma ma nwee ike ịkpata mmetụta ọjọọ. Nke a na-egosi mkpa ọ dị n'ichepụta atumatu iji kwalite ike curcumin na, ya mere, bioavailability ya.

Usoro absorption

Ịghọta usoro nke absorption curcumin dị oké mkpa maka ịmepụta usoro dị irè. A na-etinyekarị Curcumin site na mgbasa ozi na-agafe agafe n'ime sel epithelial intestinal. Otú ọ dị, adịghị ike solubility ya na gburugburu ebe obibi mmiri nke eriri afọ eriri afọ na-egbochi usoro a nke ukwuu. Ọzọkwa, curcumin nnukwu ntụ ntụ na-enweta ngwa ngwa metabolism na imeju na mgbidi eriri afọ, na-ebelata oke nke na-erute mgbasa nke sistem.

Ụzọ iji meziwanye Solubility nke Curcumin ntụ ntụ

Nyere ihe ịma aka nke curcumin adịghị mma solubility na-eweta, ndị nchọpụta na ndị nrụpụta enyochala usoro dị iche iche iji kwalite mgbasa na nnabata ya. Ụzọ ndị a na-achọ ịbawanye bioavailability nke curcumin, na-eme ka ọ dịkwuo irè na obere doses.

Nanoformulations

Usoro nanoformulation apụtala dị ka ụzọ na-ekwe nkwa maka ịkwalite curcumin solubility. Site na ibelata ihe irighiri curcumin na nha nanoscale, oke mpaghara-na-olu na-abawanye nke ukwuu, na-eme ka ọnụego mgbasa. Nanoparticles, nanoemulsions, na nanocrystals nke curcumin egosila ọganihu dị ịrịba ama na solubility na bioavailability tụnyere usoro curcumin.

Mgbagwoju anya na Cyclodextrins

Cyclodextrins, oligosaccharides cyclic nwere mpụta hydrophilic na ime hydrophobic, nwere ike mepụta ogige nsonye na curcumin. Mgbagwoju anya a na-eme ka curcumin nwee solubility mmiri ma na-echebe ya pụọ ​​​​na mmebi. Mgbakọ ndị a na-esi na ya pụta na-egosipụta profaịlụ mgbasa ozi ka mma yana mmụba bioavailability nke curcumin.

Mgbasa siri ike

Teknụzụ mgbasa siri ike gụnyere ịgbasa curcumin n'ime matriks ebu ụgbọ mmiri. Ụzọ a nwere ike ịgbanwe curcumin kristal ka ọ bụrụ ọnọdụ amorphous, na-eme ka ọ dịkwuo mfe solubility na ọnụego mgbasa. Ndị na-ebukarị ihe a na-eji na mgbasa siri ike gụnyere polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), na polymers eke dị iche iche.

Encapsulation Liposomal

Liposomes, microscopic vesicles nke nwere phospholipid bilayers, nwere ike ikpuchi curcumin, na-echebe ya pụọ ​​​​na gburugburu mmiri mmiri ma na-eme ka njem ya gafee akpụkpọ ahụ. Nhazi curcumin nke liposomal egosila nkwụsi ike emelitere, nkwalite solubility dị mma, yana mmụba ekwentị na-abawanye ma e jiri ya tụnyere curcumin efu.

Curcumin ntụ ntụ ọ na-agbaze na mmiri ma ọ bụ mmanụ?

The solubility e ji mara curcumin ntụ ntụ dị mgbagwoju anya ma dabere na ihe dị iche iche, gụnyere ihe mgbaze na ọnọdụ gburugburu ebe obibi. Ịghọta akụrụngwa ndị a dị mkpa maka ịmepụta usoro dị irè yana ịkwalite ikike ọgwụgwọ curcumin.

Water Solubility

Curcumin ntụ ntụ bụ ihe a na-apụghị imeri emeri na mmiri. Nke a hydrophobicity bụ n'ihi nhazi kemịkalụ ya, nke nwere otu phenolic na njikọ abụọ jikọtara ọnụ. Mmiri na-adịghị mma nke curcumin bụ isi ihe na-egbochi ya na bioavailability ya na ọgwụgwọ ọgwụgwọ ya. Na pH physiological, mmiri mmiri curcumin dị oke ala, e mere atụmatụ na ọ dị gburugburu 0.6 μg/mL.

Solubility mmanụ

N'adịghị ka mmiri solubility ya na-adịghị mma, curcumin na-egosipụta ezigbo solubility na mmanụ dị iche iche na ihe mgbaze organic. Ụdị lipophilic a na-enye ohere ka curcumin gbaze ngwa ngwa na abụba na mmanụ, na-eme ka ọ dị mma maka ntinye n'ime usoro dabeere na lipid. Mmanụ ndị a na-ejikarị eme ihe maka curcumin solubilization gụnyere ọkara-chain triglycerides, mmanụ aki oyibo, na mmanụ oliv.

Solubility na Organic mgbaze

Curcumin ntụ ntụ na-egosiputa ọkwa dị iche iche nke solubility na ihe mgbaze organic dị iche iche. Ọ na-agbaze nke ukwuu na ethanol na glacial acetic acid, dị ka usoro OT-42 kpebiri. A na-ejikarị solubility a na ihe ndị na-emepụta ihe na-emepụta ihe na-eme ihe na mmịpụta na ịdị ọcha nke curcumin sitere na mgbọrọgwụ turmeric. Otú ọ dị, curcumin bụ ihe a na-apụghị imeri emeri na ether, na-egbochi ngwa ya n'ụdị ụfọdụ.

Solubility dabere na pH

The solubility nke curcumin pH na-emetụta nke ukwuu. N'ọnọdụ acidic (pH <7), curcumin na-adịkarị n'ụdị protonated ya, nke na-egosipụta ogo ụfọdụ nke mmiri solubility. Otú ọ dị, na-anọpụ iche na pH alkaline, curcumin na-eweda ngwa ngwa, na-eme ka profaịlụ solubility ya dịkwuo mgbagwoju anya na gburugburu mmiri.

Mmetụta maka nhazi

Ihe dị iche iche solubility nke curcumin na mmiri na mmanụ nwere mmetụta miri emi maka nhazi ya na nnyefe ya. Usoro nke dabere na mmanụ ma ọ bụ lipid nwere ike ime ka curcumin solubility dịkwuo mma ma melite nnabata ya na eriri afọ. N'aka nke ọzọ, usoro mmiri mmiri na-achọkarị usoro solubilization ọzọ ma ọ bụ usoro ihe na-ebu iji wepụta curcumin nke ọma.

Ịkwalite Solubility Mmiri

Iji merie ụkọ mmiri na-adịghị mma nke curcumin, e mepụtala ụzọ dị iche iche. Ndị a na-agụnye iji surfactants, co-solvents, na ihe mgbagwoju anya. Dịka ọmụmaatụ, mgbakwunye nke piperine, ihe a na-ahụ na ose ojii, egosiwo na ọ na-eme ka curcumin bioavailability dị ukwuu site n'igbochi mmebi nke metabolic ya na ịba ụba ya.

Usoro Solubilization Novel

A na-enyocha usoro solubilization dị elu iji meziwanye solubility nke curcumin na-emebighị nkwụsi ike ya ma ọ bụ bioactivity. Ndị a na-agụnye mmepe nke usoro nnyefe ọgwụ na-eme onwe ya (SEDDS), polymeric micelles, na usoro dabeere na hydrogel. Ụzọ ọhụrụ ndị a na-achọ imepụta nkwadebe curcumin kwụsiri ike, na-agbaze mmiri nke na-ejigide ikike ọgwụgwọ nke ogige ahụ.

mmechi

N'ikpeazụ, solubility nke curcumin nnukwu ntụ ntụ bụ ihe dị mgbagwoju anya nke na-emetụta nke ọma bioavailability ya na ọgwụgwọ ọgwụgwọ ya. Ọ bụ ezie na curcumin na-esichaghị ike na mmiri, solubility ya na mmanụ na ihe mgbaze organic na-enye ohere maka usoro mmepụta ihe ọhụrụ. Site n'iji usoro solubilization dị elu na ịghọta njirimara solubility nke curcumin, ndị nchọpụta na ndị na-emepụta ihe nwere ike ịmepụta ngwaahịa ndị dabere na curcumin dị irè karị, nwere ike imeghe ụdịdị dị iche iche nke uru ahụike nke ogige a dị ịrịba ama.

Maka ozi ndị ọzọ gbasara ntụ ntụ curcumin na ngwa ya, biko kpọtụrụ anyị at ozi@sxrebecca.com. Ndị otu ndị ọkachamara anyị raara onwe ha nye inye mpụta ahịhịa ahịhịa dị elu ma nwee ike inyere gị aka n'ịmepụta usoro kachasị mma maka mkpa gị.

References

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2. Prasad, S., Tyagi, AK, & Aggarwal, BB (2014). Mmepe na nso nso a na nnyefe, bioavailability, absorption na metabolism nke curcumin: pigmenti ọla edo sitere na ose ọla edo. Nnyocha na ọgwụgwọ ọrịa kansa: akwụkwọ akụkọ gọọmentị Korea Cancer Association, 46(1), 2.

3. Rahmani, AH, Alsahli, MA, Aly, SM, Khan, MA, & Aldebasi, YH (2018). Ọrụ nke curcumin na mgbochi ọrịa na ọgwụgwọ. Nnyocha biomedical dị elu, 7.

4. Priyadarsini, KI (2014). Chemistry nke curcumin: site na mmịpụta gaa na onye na-ahụ maka ọgwụgwọ. Molecules, 19 (12), 20091-20112.

5. Jäger, R., Lowery, RP, Calvanese, AV, Joy, JM, Purpura, M., & Wilson, JM (2014). Ntụnyere nnabata nke usoro curcumin. Akwụkwọ nri, 13(1), 1-8