Pterostilbene nnukwu ntụ ntụ: kwalite metabolism ma chebe mkpụrụ ndụ

Pterostilbene, ogige antioxidant siri ike dị na bluuberi na mkpụrụ vaịn, enwetala nlebara anya dị ukwuu na mpaghara ahụike na ahụike. Ihe a dị ịrịba ama, dị ka pterostilbene nnukwu ntụ ntụ, na-enye ọtụtụ uru bara uru, ọkachasị n'ịkwalite metabolism na ichebe mkpụrụ ndụ site na mmebi. N'ime ntuziaka a zuru oke, anyị ga-enyocha sayensị dị n'azụ pterostilbene yana otu ọ nwere ike isi gbanwee usoro ahụike gị.

Kedu ka Pterostilbene nnukwu ntụ ntụ na-esi eme ka ọ̀tụ̀tụ̀ metabolic dịkwuo elu?

Pterostilbene, onye ikwu resveratrol, egosipụtala ike dị egwu n'ịkwalite ọrụ metabolic. Ngwakọta stilbenoid a, yana usoro kemịkalụ C16H16O3, na-arụ ọrụ na ọkwa cellular iji bulie mmepụta ike na itinye n'ọrụ.

Na-arụ ọrụ AMPK maka Metabolism emelitere

Otu n'ime isi usoro nke pterostilbene nnukwu ntụ ntụ na-akwalite metabolism bụ site na ịgbalite AMP-activated protein kinase (AMPK). Enzyme a na-arụ ọrụ dị mkpa na homeostasis ume cell, na-achịkwa glucose na metabolism lipid. Site na mkpali AMPK, pterostilbene na-enyere aka:

- Mmụba nnabata glucose na sel akwara

- kwalite fatty acid oxidation

- Kwalite biogenesis mitochondrial

Omume ndị a na-enye aka n'otu n'otu na-eme ka arụ ọrụ metabolic ka mma yana mmụba ume ike.

Na-ahazi ọkwa shuga ọbara

Pterostilbene nnukwu ntụ ntụ egosila ikike dị ịrịba ama n'ịhazi ọkwa glucose ọbara. Nnyocha egosiwo na ọ nwere ike:

- Mee ka insulin nwee mmetụta

- Belata mmepụta glucose na imeju

- Meziwanye nnabata glucose na anụ ahụ dị n'akụkụ

Site n'ịkwado ọkwa shuga dị n'ọbara kwụsiri ike, pterostilbene na-enyere aka igbochi mkpọka ike ma na-akwalite ọrụ metabolic na-adịgide adịgide n'ụbọchị niile.

Na-akwado Lipid Metabolism

Akụkụ ọzọ dị ịrịba ama nke uru metabolic pterostilbene bụ na ikike ya ịkwado metabolism lipid dị mma. Nnyocha egosiwo na pterostilbene nwere ike:

- mbelata ọkwa LDL cholesterol

- Mmụba HDL cholesterol

- belata triglycerides

Mmetụta ndị a ọ bụghị naanị na-eme ka ahụike metabolic dịkwuo mma kamakwa na-akwado ịdị mma nke obi.

Uru Nchekwa Cellular nke Pterostilbene nnukwu ntụ ntụ

E wezụga mmetụta metabolic ya, pterostilbene nnukwu ntụ ntụ na-enye uru nchebe cellular dị ike. Njirimara antioxidant ya na ikike imegharị ụzọ cellular dị iche iche na-eme ka ọ bụrụ ngwá ọrụ bara uru n'ịkwalite ahụike na ogologo ndụ n'ozuzu ya.

Ọrụ Antioxidant dị ike

Pterostilbene bụ antioxidant siri ike, nke nwere ike iwepụ radicals efu na-emerụ ahụ yana ibelata nrụgide oxidative. Ọrụ antioxidant ya dị ịrịba ama n'ihi na:

- Ọ dị bioavailable karịa ọtụtụ antioxidants ndị ọzọ

- Ọ nwere ike ịgafe ihe mgbochi ụbụrụ ọbara, na-enye neuroprotection

- Ọ nwere ogologo ndụ ọkara ndụ n'ime ahụ ma e jiri ya tụnyere ogige ndị yiri ya

Njirimara ndị a na-eme ka pterostilbene nnukwu ntụ ntụ bụrụ nhọrọ magburu onwe ya maka ndị na-achọ nchebe cellular zuru oke.

Nchekwa DNA na ndozi

Otu n'ime akụkụ kachasị mkpa nke ahụike sel bụ idobe iguzosi ike n'ezi ihe DNA. Pterostilbene egosila ikike:

- Chebe DNA pụọ na mmebi oxidative

- Melite usoro nrụzi DNA

- Belata nguzobe nke DNA adducts

Site na ichekwa mkpụrụ ndụ ihe nketa, pterostilbene na-enyere aka ịnọgide na-arụ ọrụ cellular ma na-egbochi mmụgharị nke nwere ike ibute nsogbu ahụike dị iche iche.

Mmetụta Ọ Na-egbochi Ahụhụ

Ọrịa na-adịghị ala ala bụ ihe na-akpata ọtụtụ ọrịa ndị metụtara afọ. Pterostilbene nnukwu ntụ ntụ na-egosipụta ihe mgbochi mkpali dị ike site na:

- Na-egbochi cytokines pro-inflammatory

- Mbelata ịgbalite ụzọ mkpali

- Modulating nzaghachi mgbochi

Mmetụta mgbochi mkpali ndị a na-enye aka na ahụike sel n'ozuzu ma nwee ike inye aka gbochie ọnọdụ dị iche iche na-adịghị ala ala.

Kedu ihe kpatara Pterostilbene nnukwu ntụ ntụ ji dị mkpa maka ịdị mma?

Nchikota nke nkwalite metabolic na nchebe cellular na-eme ka pterostilbene nnukwu ntụ ntụ bụrụ ihe bara uru na mgbakwunye na usoro ahụike ọ bụla. Uru ya nwere ọtụtụ ihe na-eleba anya n'ọtụtụ akụkụ dị mkpa nke ahụike na ogologo ndụ.

Ọrụ cognitive na Neuroprotection

Ọrịa Pterostilbene ikike ịgafe ihe mgbochi ụbụrụ ọbara na-eme ka ọ baara uru karịsịa maka ahụike uche. Nnyocha na-egosi na ọ nwere ike:

- Melite ebe nchekwa na mmụta

- Belata mbelata ọgụgụ isi metụtara afọ

- Chebe megide ọrịa neurodegenerative

Mmetụta neuroprotective ndị a na-eme ka pterostilbene nnukwu ntụ ntụ bụrụ nhọrọ magburu onwe ya maka ndị na-achọ ịnọgide na-arụ ọrụ ọgụgụ isi ka ha na-eme agadi.

Nkwado ahụike obi obi

Metabolism na antioxidant Njirimara nke pterostilbene na-enyere aka nke ukwuu na ahụike obi. Oriri pterostilbene nnukwu ntụ ntụ mgbe niile nwere ike:

- Melite profaịlụ lipid

- Belata ọbara mgbali elu

- kwalite ọrụ endothelial

Uru ndị a nwere ike itinye aka na mbelata ihe ize ndụ nke ọrịa obi yana imeziwanye ịdị mma obi n'ozuzu ya.

Njirimara mgbochi ọrịa cancer nwere ike

Ọ bụ ezie na achọrọ nyocha ndị ọzọ, nchọpụta mbụ egosila nsonaazụ na-ekwe nkwa gbasara ihe nwere ike igbochi ọrịa cancer pterostilbene. Ọ nwere ike:

- akpalite apoptosis n'ime mkpụrụ ndụ kansa

- Na-egbochi mgbasa mkpụrụ ndụ kansa

- Belata angiogenesis na etuto ahụ

Ọ bụ ezie na ọ bụghị onye na-anọchi anya ọgwụgwọ ọrịa cancer na-emekarị, pterostilbene nnukwu ntụ ntụ nwere ike inye nkwado ọzọ na mgbochi ọrịa cancer na usoro nlekọta.

Ogologo ndụ na ịka nká

Mmetụta mkpokọta nke pterostilbene metabolic, antioxidant, na ihe nchebe cellular na-enye aka na ịka nká. Oriri pterostilbene nnukwu ntụ ntụ mgbe niile nwere ike:

- Belata nrụgide oxidative metụtara ịka nká

- Kwado mmepụta ike cell

- Debe iguzosi ike n'ezi ihe DNA

Uru ndị a na-eme ka pterostilbene bụrụ ihe mgbakwunye magburu onwe ya na usoro ahụike ọ bụla lekwasịrị anya ogologo ndụ.

mmechi

Pterostilbene nnukwu ntụ ntụ na-anọchi anya mgbakwụnye ọnụ n'akụkụ ahụike na ịdị mma. Ikike ya ịkwalite metabolism, chebe sel, na ịkwado ahụike zuru oke na-eme ka ọ bụrụ mgbakwunye bara uru na usoro ahụike ọ bụla. Ka nyocha na-aga n'ihu na-ekpughe ikike zuru oke nke onyinye a dị ịrịba ama, o doro anya na pterostilbene nwere oke ọrụ ọ ga-arụ n'ịkwalite ogologo ndụ na ume ike.

Ọ bụrụ na ị nwere mmasị itinye pterostilbene nnukwu ntụ ntụ n'ime usoro ahụike gị, ọ dị mkpa ịhọrọ ngwaahịa dị elu. Chọọ maka pterostilbene ntụ ntụ na opekempe ịdị ọcha nke 99%, nke nyocha HPLC kwadoro. Ọ bụ ezie na pterostilbene enweghị ike ime na mmiri, enwere ike ịgbaze ya na methanol na-ekpo ọkụ ma ọ bụ DMSO maka ngwa dị iche iche. Maka ozi ndị ọzọ gbasara pterostilbene nnukwu ntụ ntụ na uru ọ nwere, biko kpọtụrụ anyị at ozi@sxrebecca.com. Ndị otu ndị ọkachamara anyị dị njikere inyere gị aka ịchọta ngwaahịa pterostilbene ziri ezi maka mkpa gị.

References

1. McCormack, D., & McFadden, D. (2013). Nyochaa ọrụ antioxidant pterostilbene na mgbanwe ọrịa. Ọgwụ Oxidative na Ogologo ndụ Cellular, 2013, 575482.

2. Kosuru, R., Rai, U., Prakash, S., Singh, A., & Singh, S. (2016). Pterostilbene na-ebelata nrụgide oxidative obi na mbufụt site na ịgbalite ụzọ AMPK / Nrf2 / HO-1 n'ime oke ndị na-arịa ọrịa shuga fructose. Ọgwụ na ọgwụgwọ obi obi, 30 (5), 463-474.

3. Estrela, JM, Ortega, A., Mena, S., Rodriguez, ML, & Asensi, M. (2013). Pterostilbene: Ngwa biomedical. Nlebanya dị egwu na sayensị ụlọ nyocha ahụike, 50(3), 65-78.

4. Tsai, HY, Ho, CT, & Chen, YK (2017). Omume ndu na mmetụta molekụla nke resveratrol, pterostilbene, na 3'-hydroxypterostilbene. Akwụkwọ akụkọ nke nyocha nri na ọgwụ ọjọọ, 25 (1), 134-147.

5. Kapetanovic, IM, Muzzio, M., Huang, Z., Thompson, TN, & McCormick, DL (2011). Pharmacokinetics, bioavailability ọnụ, na profaịlụ metabolic nke resveratrol na dimethylether analog, pterostilbene, na oke. Chemotherapy na nkà mmụta ọgwụ maka ọrịa kansa, 68 (3), 593-601.