Pterostilbene kacha mma: ike antioxidant na ogologo ndụ

Pterostilbene, ogige antioxidant siri ike, na-enweta nlebara anya dị ukwuu na ụwa ahụike na ịdị mma. Molecule a dị ịrịba ama, nke a na-ahụ n'onwe ya na blueberries na osisi ndị ọzọ, na-aghọ ngwa ngwa ebe ndị na-eme nchọpụta na-enyocha ụzọ isi kwalite ogologo ndụ na ịlụso ọrịa ndị metụtara afọ ọgụ. N'ime ntuziaka a zuru oke, anyị ga-enyocha ụwa nke na-adọrọ mmasị pterostilbene kacha mma, na-enyocha njirimara antioxidant ya, uru ogologo ndụ nwere ike ime, na nchọpụta sayensị na-akwado ọtụtụ uru ahụike ya.

Kedu ihe kpatara Pterostilbene ji bụrụ Antioxidant siri ike?

Pterostilbene bụ klaasị nke ogige a na-akpọ polyphenols, bụ ndị a ma ama maka njirimara antioxidant ha. Dị ka antioxidant, pterostilbene na-arụ ọrụ dị mkpa n'ichebe mkpụrụ ndụ anyị pụọ na nrụgide oxidative na mmebi nke radicals efu kpatara. Ụmụ irighiri ihe ndị a na-emerụ ahụ nwere ike imebi akụkụ cellular anyị, na-eduga n'ịka nká na nsogbu ahụike dị iche iche.

Ihe na-eme ka pterostilbene dị iche na antioxidants ndị ọzọ bụ usoro ihe omimi ya pụrụ iche. Ọ bụ analọgụ dimethylated nke resveratrol, antioxidant ọzọ a ma ama nke dị na mmanya uhie. Obere ọdịiche dị na nhazi a na-enye pterostilbene ụfọdụ uru dị iche iche:

-Enwewanye bioavailability: Pterostilbene na-abanye ngwa ngwa site na ahụ ma e jiri ya tụnyere resveratrol, na-eme ka ọ dịkwuo irè karị.

- Nkwụsi ike na-abawanye: Ngwakọta ahụ na-anọgide na-arụ ọrụ n'ime ahụ ruo ogologo oge, na-agbatị mmetụta bara uru ya.

- lipophilicity kachasị elu: Pterostilbene nwere ike ịbanye n'ime membranes cell n'ụzọ dị mfe, na-enye ya ohere itinye mmetụta antioxidant ya n'ime sel nke ọma.

Ngwongwo ndị a na-eme pterostilbene ka ọ bụrụ antioxidant siri ike, nke nwere ike iwepụ radicals efu na ibelata nrụgide oxidative n'ime ahụ dum. Site n'ime nke a, ọ na-enyere aka ichebe mkpụrụ ndụ anyị pụọ na mmebi nke nwere ike ibute ịka nká ngwa ngwa na nsogbu ahụike dị iche iche.

Ọzọkwa, ike antioxidant pterostilbene gbatịrị karịa naanị iwepu radicals efu. Nnyocha na-egosi na ọ nwekwara ike ịkwalite ihe nchebe antioxidant nke anụ ahụ site n'ịgbalite ụfọdụ mkpụrụ ndụ ihe nketa na enzymes na-etinye aka na mmepụta antioxidant. Omume abụọ a - na-alụso ọgụ ọgụ n'efu ka ọ na-akwalite sistemu antioxidant dị n'ime anyị - na-eme pterostilbene ka ọ bụrụ onye mmekọ siri ike na ọgụ megide nrụgide oxidative.

Kedu ka Pterostilbene si akwalite ogologo ndụ?

Nchụso ogologo ndụ ogologo oge bụ isi ihe nyocha sayensị, na pterostilbene kacha mma aputala dika onye ndoro-ndoro ochichi n'ọchichọ a. Ike ya ịkwalite ogologo ndụ sitere na usoro dị iche iche bụ isi:

Nchekwa DNA

Otu n'ime ụzọ pterostilbene nwere ike isi nye aka na ogologo ndụ bụ site n'ikike ya ichekwa DNA anyị. Ka anyị na-aka nká, DNA anyị na-akwakọba mmebi site na isi mmalite dị iche iche, gụnyere nrụgide oxidative. Nbibi a nwere ike ibute mmụgharị na arụ ọrụ cellular, n'ikpeazụ na-enye aka na usoro ịka nká na ọrịa ndị metụtara afọ. Ngwongwo antioxidant siri ike nke Pterostilbene na-enyere aka chebe ihe mkpụrụ ndụ ihe nketa anyị pụọ na mmerụ ahụ, nwere ike ibelata usoro ịka nká na ọkwa cellular.

Mmepụta ike cellular

E gosipụtara Pterostilbene iji kwado ọrụ mitochondrial. Mitochondria bụ ụlọ ike nke mkpụrụ ndụ anyị, na-ahụ maka imepụta ike achọrọ maka usoro cellular. Ka anyị na-aka nká, ọrụ mitochondrial na-agbadata, na-eduga n'ịbelata mmepụta ume na ụbara nrụgide oxidative. Site n'ịkwado ahụike mitochondrial, pterostilbene nwere ike inye aka ịnọgide na-enwe ike ike cellular yana ike zuru ezu ka anyị na-eme agadi.

Mbelata Mbufụt

Ọrịa na-adịghị ala ala, nke dị ala bụ ihe e ji mara ịka nká ma na-ebute ọtụtụ ọrịa ndị metụtara afọ. Pterostilbene na-egosiputa ihe ndị nwere ike igbochi mkpali, na-enyere aka ịkwụsị usoro a "ọkụ". Site na ibelata mbufụt nke sistem. pterostilbene nwere ike inye aka gbochie ma ọ bụ belata ọnọdụ dị iche iche metụtara afọ, nwere ike ịgbatị ma ogologo ndụ yana ogologo ahụike.

Ahụike Metabolic

Ịkwado ahụike nke metabolic dị oke mkpa maka ogologo ndụ, na pterostilbene na-egosikwa nkwa na mpaghara a. Nnyocha e mere egosiwo na ọ nwere ike inye aka ịhazi ọkwa shuga dị n'ọbara, meziwanye mmetụta insulin, na ịkwado profaịlụ lipid dị mma. Mmetụta ndị a nwere ike itinye aka na mbelata ihe ize ndụ nke ọrịa metabolic na nsogbu ndị metụtara ya, nwere ike ịgbatị ndụ.

neuroprotection

Mbelata ọgụgụ isi bụ ihe na-emetụtakarị ka anyị na-aka nká. Pterostilbene egosipụtawo ihe ndị na-adịghị ahụkebe na nyocha dị iche iche, na-atụ aro na ọ nwere ike inye aka ịnọgide na-arụ ọrụ ọgụgụ isi ma chebe megide neurodegeneration metụtara afọ. Site n'ịkwado ahụike ụbụrụ, pterostilbene nwere ike inye aka na-edobe ịdịmma ndụ na nnwere onwe n'afọ ndị ọzọ.

Nnyocha sayensị na-akwado uru ahụike Pterostilbene

Uru ahụike nke pterostilbene nwere ike ịbụ isiokwu nke ọtụtụ ọmụmụ sayensị. Ọ bụ ezie na nyocha na-aga n'ihu, ihe akaebe dị ugbu a na-egosi na pterostilbene nwere ike inye ọtụtụ uru ahụike:

Ike Ọrịa

Ọtụtụ ọmụmụ enyochala uru pterostilbene nwere ike ime maka obi. Otu nnyocha e bipụtara na Journal of Agricultural and Food Chemistry chọpụtara na pterostilbene nyere aka belata ọbara mgbali elu ma melite profaịlụ lipid na hamsters na-eri nri cholesterol dị elu. Nnyocha ọzọ na Vascular Pharmacology gosipụtara na pterostilbene nwere ike ichebe mmerụ ahụ nke LDL na-akpata oxidized, na-atụ aro ọrụ nwere ike igbochi atherosclerosis.

Ọrụ ọgụgụ isi

Achọpụtala ihe ndị na-akpata neuroprotective Pterostilbene n'ọmụmụ ihe dị iche iche. Nnyocha e bipụtara na Neurobiology of Aging gosiri na pterostilbene kwalitere arụmọrụ ọgụgụ isi yana nguzogide nrụgide cellular na oke oke. Nnyocha ọzọ na Journal of Neurochemistry chọpụtara na pterostilbene echebe megide nrụgide oxidative na-akpata ọnwụ neuronal, na-atụ aro ngwa ndị nwere ike igbochi ọrịa neurodegenerative.

Ọrịa shuga

Achọpụtala ikike Pterostilbene nwere ike ime ka ahụike metabolic dịkwuo mma n'ọtụtụ ọmụmụ. Nnyocha e bipụtara na Journal of Agricultural and Food Chemistry gosiri na pterostilbene kwalitere hyperglycemia na hyperlipidemia na oke ndị na-arịa ọrịa shuga. Nnyocha ọzọ na Molecular Nutrition & Food Research gosipụtara na pterostilbene nwere ike ịkwalite mmetụta insulin ma belata ọkwa glucose ọbara na oke oke.

Imeju Ahụ ike

Ụfọdụ ọmụmụ na-atụ aro na pterostilbene nwere ike ịnwe ihe mgbochi hepatoprotective. Nnyocha e mere na Journal of Nutritional Biochemistry chọpụtara na pterostilbene nwere ike ichebe imeju imeju site na nri nwere oke abụba na ụmụ oke. Nnyocha ọzọ na Food and Chemical Toxicology gosipụtara ikike pterostilbene iji chebe megide mmebi imeju nke ọgwụ kpatara.

mmechi

Pterostilbene pụtara dị ka onyinye na-ekwe nkwa na mpaghara nke antioxidants na ihe na-akwalite ogologo ndụ. Ngwongwo antioxidant ya siri ike, yana ikike ya nwere ike imetụta akụkụ dị iche iche nke ahụike - site na ọrụ obi ruo n'ịrụ ọrụ ọgụgụ isi - na-eme ka ọ bụrụ isiokwu na-adọrọ mmasị maka nyocha na-aga n'ihu. Maka ozi ndị ọzọ gbasara pterostilbene kacha mma na ihe ndi ozo sitere n'okike, biko kpọtụrụ anyị at ozi@sxrebecca.com.

References

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2. Rimando, AM, & Suh, N. (2008). Ọrụ ndu / chemopreventive nke stilbenes na mmetụta ha na ọrịa kansa eriri afọ. Planta Medica, 74 (13), 1635-1643.

3. Kapetanovic, IM, Muzzio, M., Huang, Z., Thompson, TN, & McCormick, DL (2011). Pharmacokinetics, bioavailability ọnụ, na profaịlụ metabolic nke resveratrol na dimethylether analog, pterostilbene, na oke. Chemotherapy na nkà mmụta ọgwụ maka ọrịa kansa, 68 (3), 593-601.

4. Kosuru, R., Rai, U., Prakash, S., Singh, A., & Singh, S. (2016). Nkwa na-ekwe nkwa ọgwụgwọ nke pterostilbene na nghọta usoro ya dabere na ihe akaebe izizi. Akwụkwọ akụkọ European nke Pharmacology, 789, 229-243.

5. Agarwal, S., Yadav, A., & Chaturvedi, RK (2017). Peroxisome proliferator-activated receptors (PPARs) dị ka ebumnuche ọgwụgwọ na ọrịa neurodegenerative. Nkwukọrịta nyocha nke biochemical na Biophysical, 483(4), 1166-1177.